ncRNA name | KCNQ1OT1 |
ncRNA Category | lncRNA |
ID | 10984 |
Ensembl | ENSG00000269821 |
Synonyms | LIT1; Kncq1; KvDMR1; KCNQ10T1; KCNQ1-AS2; KvLQT1-AS; NCRNA00012 |
Disease name | cataract |
Species | Homo sapiens |
Tissues/Cell_line | lens anterior capsular samples; human lens epithelial cell line SRA01/04 |
Methods | qRT-PCR, Western blot, immunofluorescence staining, TUNEL assay, luciferase reporter assay |
Expression pattern | up-regulated |
Functional description | Knockdown of KCNQ1OT1 expression significantly suppressed H2O2-induced SRA01/04 cell pyroptosis in vitro, which is the critical step in cataract formation. Knockdown of KCNQ1OT1 significantly increased the expression of miR-214. |
PubMed ID | 28535504 |
Year | 2017 |
Title | Long Non-Coding RNA KCNQ1OT1 Promotes Cataractogenesis via miR-214 and Activation of the Caspase-1 Pathway. |
Drug-related ncRNA | NO |
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